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DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat
Published on: February 27, 2014
What's new in IBD therapy: An "omics network" approach
Claudio Fiocchi1, Dimitrios Iliopoulos2
1Department of Inflammation & Immunity, Lerner Research Institute, USA; Department of Gastroenterology, Hepatology and Nutrition, Digestive Disease and Surgery Institute Cleveland Clinic, Cleveland, OH, USA.
Chronic inflammatory diseases like inflammatory bowel diseases (IBD) have emerged due to rapid environmental and lifestyle changes. Current treatments are insufficient, necessitating a network medicine approach for improved IBD therapy.
Area of Science:
- Gastroenterology
- Immunology
- Systems Biology
Background:
- The Industrial Revolution triggered significant environmental and lifestyle shifts, contributing to the rise of chronic inflammatory diseases.
- Inflammatory Bowel Diseases (IBD), including ulcerative colitis and Crohn's disease, are complex conditions with increasing prevalence.
- Despite advancements in biological therapies, current treatments for IBD show limited efficacy and durability.
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