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3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
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Migraine Aura: Updates in Pathophysiology and Management.
1Department of Medicine, Division of Neurology, University of British Columbia, Vancouver, Canada.
Current Neurology and Neuroscience Reports
|May 21, 2020
Summary
Migraine with aura pathophysiology is complex, involving subcortical regions and cortical spreading depression (CSD). Current research uses new models and neuroimaging to understand migraine aura, with no specific therapies yet available.
Area of Science:
- Neurology
- Neuroscience
- Medical Research
Background:
- Migraine with aura is a complex neurological disorder.
- Understanding its pathophysiology, including the role of subcortical regions and cortical spreading depression (CSD), is ongoing.
- Variability in aura symptoms, particularly visual aura, exists between and within patients.
Purpose of the Study:
- To review the current understanding of migraine with aura pathophysiology.
- To outline diagnostic approaches for migraine with aura.
- To discuss current management strategies for migraine with aura.
Main Methods:
- Review of existing literature on migraine with aura.
- Inclusion of recent findings on pathophysiology.
- Consideration of novel experimental models and diagnostic tools like neuroimaging.
Main Results:
- Subcortical regions may contribute to migraine pathophysiology.
- Migraine with brainstem aura might originate cortically, and retinal aura may involve retinal changes.
- Cortical spreading depression (CSD) remains a key theory, but its precise role in all migraine phases is not fully elucidated.
- Differential diagnosis must include transient ischemic attacks, stroke, and epilepsy.
- Currently, no specific therapies exist for migraine with aura.
Conclusions:
- Further research using advanced models and neuroimaging is needed to fully understand migraine with aura.
- Accurate diagnosis requires considering other neurological conditions.
- Management remains symptomatic due to the lack of specific treatments.
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