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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Desmosomes01:05

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The term desmosome derives from the Greek words "desmo" and "soma" meaning "adhesion bodies." This structure was first observed during the late 1800s and described as small, dense nodules in the epidermis. Desmosomes are button-like structures that help form an interlinked network of intermediate filaments across the cells. These junctions are  essential to hold cells together under mechanical stress and to maintain tissue integrity. Desmosomes are multi-protein...
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Related Experiment Video

Updated: Dec 20, 2025

A 3D Organotypic Melanoma Spheroid Skin Model
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A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

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[Mixed desmoplastic melanoma].

Carina Simionato1, Carla Minaudo1, Tomás Mosquera1

  • 1Servicio Dermatología, Hospital Británico de Buenos Aires, Argentina.

Medicina
|May 23, 2020
PubMed
Summary
This summary is machine-generated.

Desmoplastic melanoma, a rare skin cancer variant, presents diagnostic challenges due to its varied appearance and lack of pigment. Despite a higher average thickness, it shows a low tendency for lymph node metastasis.

Keywords:
amelanotic melanomadesmoplastic melanomapure and mixed desmoplastic melanoma

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Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Desmoplastic melanoma is a rare histological variant of cutaneous melanoma.
  • It exhibits distinct clinical behavior and diagnostic challenges compared to other melanoma types.

Observation:

  • Diagnosis is difficult due to variable presentation, predominantly dermal component, and frequent amelanosis (lack of pigment).
  • Histological classification includes pure and mixed types, impacting prognosis.

Findings:

  • The average Breslow thickness at diagnosis is greater than in other melanoma variants.
  • Despite increased thickness, the propensity for lymph node metastasis is notably low.

Implications:

  • Early diagnosis of desmoplastic melanoma requires heightened clinical suspicion.
  • Understanding its unique prognostic factors is crucial for patient management and treatment strategies.