[Non-skeletal forms of fluorosis].

Area of Science:

• Toxicology
• Pathology
• Biochemistry

Context:

• Fluorosis is a public health concern associated with chronic fluorine exposure.
• Skeletal fluorosis is well-documented, but nonskeletal manifestations require further investigation.

Purpose:

• To elucidate the pathological changes in nonskeletal tissues during chronic fluorine intoxication.
• To establish the concept of a preskeletal phase of fluorosis characterized by early soft tissue damage.

Summary:

• This study reviews nonskeletal forms of fluorosis, detailing pathological changes in the central nervous system, skeletal muscles, stomach, liver, kidney, cardiovascular system, retina, and skin.
• Evidence suggests that soft tissue disturbances occur early in chronic fluorine intoxication, preceding typical dental and skeletal alterations.
• These early changes signify a distinct preskeletal phase of fluorosis.

Impact:

• Highlights the importance of monitoring soft tissue health in populations exposed to fluorine.
• Provides a framework for understanding the early stages of fluorosis, potentially leading to earlier diagnosis and intervention.
• Emphasizes the systemic effects of fluorine beyond skeletal tissues.