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Naloxone fails to alter local cerebral glucose utilization in the rat
R J Fanelli1, R C Walovitch, D R Jasinski
1Neuropharmacology Laboratory, National Institute on Drug Abuse, Baltimore, MD 21224.
Pharmacology, Biochemistry, and Behavior
|October 1, 1988
Abstract:
The autoradiographic, 2-deoxy-D-[1-14C]glucose ([14C]DG) method was used to map the effects of intravenous (IV) naloxone (1.0, 10.0, and 20.0 mg/kg) on local cerebral glucose utilization (LCGU), an index of local brain function. Naloxone injected 5 min before [14C]DG did not alter LCGU in any of the fifty-six brain regions examined. Our findings suggest that acute naloxone at these doses does not significantly affect cerebral metabolism.