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Hepatitis B reactivation: diagnosis and management
Shang-Chin Huang1, Hung-Chih Yang1,2,3, Jia-Horng Kao1,2,4,5
1Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Taiwan University Hospital , Taipei, Taiwan.
Expert Review of Gastroenterology & Hepatology
|May 26, 2020
Summary
Preventing Hepatitis B virus (HBV) reactivation requires universal screening and risk stratification. Early diagnosis and antiviral prophylaxis are key to managing HBV reactivation effectively and avoiding severe outcomes.
Area of Science:
- Hepatology
- Immunology
- Virology
Background:
- Hepatitis B virus (HBV) reactivation poses significant risks, increasing morbidity and mortality.
- Treatment-induced immune suppression can trigger HBV reactivation.
- Risk factors include host immunity, viral characteristics, and treatment type/dosage.
Purpose of the Study:
- To review current evidence and recommendations for managing HBV reactivation.
- To address the uncertainty surrounding HBV reactivation risk with novel therapies.
Main Methods:
- Literature review of the latest evidence.
- Synthesis of recommendations for risk stratification, diagnosis, prophylaxis, and management.
Main Results:
- Risk stratification and prophylactic antiviral agents are critical for prevention.
- Emerging biomarkers aid in precise risk determination.
- Early diagnosis and prompt antiviral treatment are essential for effective management.
Conclusions:
- Universal screening, prophylaxis, and monitoring are vital for HBV reactivation prevention.
- Individualized strategies require further research on risk stratification precision and optimal prophylaxis/treatment duration.
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