Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

497
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
497
Lipid Catabolism01:25

Lipid Catabolism

705
Triglycerides serve as crucial long-term energy storage molecules in microorganisms, providing a dense source of metabolic energy. Their breakdown is mediated by lipases, which hydrolyze triglycerides into glycerol and free fatty acids. Each of these components follows distinct metabolic pathways, ultimately contributing to ATP synthesis and cellular energy homeostasis.Glycerol MetabolismGlycerol, released from triglyceride hydrolysis, is phosphorylated by glycerol kinase to form...
705
Lipid Digestion01:06

Lipid Digestion

98.2K
Lipids are large molecules that are generally not water-soluble. Since most of the digestive enzymes in the human body are water-based, there are specific steps the body must take to break down lipids and make them available for use.
98.2K
Overview of Lipid Metabolism01:24

Overview of Lipid Metabolism

4.4K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
4.4K
Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

1.2K
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
1.2K
Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

1.2K
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
1.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of evolocumab on plasma coenzyme Q10 in patients with heterozygous familial hypercholesterolemia.

Atherosclerosis plus·2026
Same author

Efficacy and Safety of Evinacumab in Japanese Patients with Homozygous Familial Hypercholesterolemia: Long-term Results from an Open-label, Single-arm, Phase 3 Trial.

Journal of atherosclerosis and thrombosis·2026
Same author

Distribution of Lipoprotein(a) Levels Among Children with Elevated Low-Density Lipoprotein Cholesterol Identified Through Universal Pediatric Lipid Screening.

Journal of atherosclerosis and thrombosis·2026
Same author

Sex Differences in the Diagnosis and Treatment of Japanese Patients With Familial Hypercholesterolemia: A Retrospective Cohort Study.

Journal of lipid and atherosclerosis·2026
Same author

Current and Future Perspectives of LDL-C Lowering Therapies 2026.

Journal of atherosclerosis and thrombosis·2026
Same author

Severe HDL-C Deficiency Caused by Acquired LCAT Deficiency: A Case Report with Lipidomic Profiling and Anti-LCAT Autoantibody Detection.

Internal medicine (Tokyo, Japan)·2026
Same journal

Cardiovascular disease and miRNA.

Advances in clinical chemistry·2026
Same journal

RNA biomarkers in antidoping.

Advances in clinical chemistry·2026
Same journal

Biomarkers for assessing magnesium status.

Advances in clinical chemistry·2026
Same journal

Advances in microfluidic extracellular vesicle technology.

Advances in clinical chemistry·2026
Same journal

Chronic low-grade inflammation in vegetarians and vegans: Biomarker evidence and methodological considerations.

Advances in clinical chemistry·2026
Same journal

Biomarkers in heart failure.

Advances in clinical chemistry·2026
See all related articles

Related Experiment Video

Updated: Dec 20, 2025

Assessing Whole-Body Lipid-Handling Capacity in Mice
07:57

Assessing Whole-Body Lipid-Handling Capacity in Mice

Published on: November 24, 2020

4.6K

Genomics of hypertriglyceridemia.

Hayato Tada1, Masayuki Takamura1, Masa-Aki Kawashiri1

  • 1Department of Cardiology, Kanazawa University, Graduate School of Medical Sciences, Kanazawa, Japan.

Advances in Clinical Chemistry
|May 26, 2020
PubMed
Summary
This summary is machine-generated.

Serum triglyceride levels are highly heritable, with 50% of variation from parents and 50% modifiable by environment. Triglycerides are key risk factors for atherosclerotic cardiovascular disease (ASCVD), alongside LDL.

Keywords:
ASCVDCholesterolGeneticsLDLTriglycerides

More Related Videos

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation
06:47

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation

Published on: January 28, 2021

12.2K
Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF
03:42

Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF

Published on: March 29, 2024

1.9K

Related Experiment Videos

Last Updated: Dec 20, 2025

Assessing Whole-Body Lipid-Handling Capacity in Mice
07:57

Assessing Whole-Body Lipid-Handling Capacity in Mice

Published on: November 24, 2020

4.6K
Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation
06:47

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation

Published on: January 28, 2021

12.2K
Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF
03:42

Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF

Published on: March 29, 2024

1.9K

Area of Science:

  • Genetics and Cardiovascular Health

Background:

  • Serum triglyceride levels exhibit high heritability, with approximately 50% of variability attributed to genetic factors.
  • Lipoproteins, particularly low-density lipoprotein (LDL), are established causal factors for atherosclerotic cardiovascular disease (ASCVD).
  • Triglyceride-rich lipoproteins are increasingly recognized as residual targets for ASCVD risk reduction, especially in the context of LDL-lowering therapies.

Purpose of the Study:

  • To review the genetic determinants of triglyceride levels.
  • To explore insights from severe hypertriglyceridemia cases.
  • To highlight the clinical and genetic evidence linking triglycerides to ASCVD risk.

Main Methods:

  • Review of genetic heritability studies for serum triglyceride levels.
  • Analysis of clinical data from patients with severe hypertriglyceridemia.
  • Examination of epidemiological and Mendelian randomization studies on triglyceride-APOB associations with ASCVD.

Main Results:

  • Approximately 50% of triglyceride variability is heritable, with the remainder influenced by environmental factors.
  • Both fasting and non-fasting triglycerides show significant associations with ASCVD.
  • Apolipoprotein B (APOB) may serve as a superior marker for ASCVD risk compared to separate assessments of LDL and triglyceride-rich lipoproteins.

Conclusions:

  • Triglycerides play a critical role in ASCVD pathogenesis, influenced by both genetic and environmental factors.
  • Understanding triglyceride metabolism and its genetic basis is crucial for comprehensive ASCVD risk management.
  • APOB measurement offers a potentially more integrated approach to assessing lipoprotein-related ASCVD risk.