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Heart aging when near vision difficulty begins
Şahbender Koç1, Sadettin Selçuk Baysal2
1Keçiören Education and Training Hospital, Unıversity of Health Sciences, Ankara, Turkey.
Insights
Measuring near vision with a simple test can identify signs of cardiac aging. Reduced accommodation amplitude (AA) is linked to increased risk of diastolic dysfunction and other heart aging indicators.
Area of Science:
- Ophthalmology
- Cardiology
- Gerontology
Background:
- Cellular aging affects non-renewable tissues like the heart and lens more than renewable ones.
- Declining accommodation amplitude (AA) is a hallmark of age-related near vision loss.
- Cardiac aging is a significant, independent risk factor for cardiovascular diseases.
Purpose of the Study:
- To investigate the association between cardiac aging and accommodation amplitude (AA).
- To explore if AA measurement can serve as a screening tool for cardiac aging.
Main Methods:
- 500 participants (mean age 50) were grouped by AA measured with a Raf ruler.
- Lens nucleus changes during accommodation were imaged via biomicroscopy and measured using ImageJ.
- Cardiac aging was assessed using electrocardiography, heart rate variability, and diastolic dysfunction evaluation.
Main Results:
- Subjects with reduced near vision clarity (29-33 cm) showed a 2.6-fold higher risk of diastolic dysfunction.
- These subjects also had a 2.1-fold higher risk of reduced lateral e' velocity and a 1.5-fold higher risk of an abnormal low/high frequency ratio.
Conclusions:
- Subjective accommodation amplitude (AA) measurement is a simple screening method.
- AA can predict key cardiac aging parameters, notably diastolic dysfunction.
Objectives:
Heart, lens, and neuronal cells change significantly with age, and they are older than cells from renewable tissues. Near vision deterioration during aging results from a decrease in accommodation amplitude (AA). Cardiac aging is an independent risk factor for cardiovascular disease. We investigated the association between cardiac aging and AA.
Methods:
The subjects (500 mean 50-year-old subjects, with equal males and females) were divided into two groups according to AA measured with a Raf ruler. Biomicroscopy was used to capture images of the lens nucleus in the unaccommodated and accommodated state. The nucleus diameter change at 1 D accommodation was measured using ImageJ. Cardiac conduction system differences were evaluated using electrocardiography, and cardiac autonomic aging was assessed based on heart rate variability. Myocardial aging was assessed based on diastolic dysfunction.
Results:
For near distance vision, compared to subjects who could see clearly from 24 to 28 cm, subjects who could see clearly from 29 to 33 cm had a 2.104-fold higher risk of a lateral e' velocity <10 cm/s [95%CI: 1.312-3.374], 2.603-fold higher risk of diastolic dysfunction [95%CI: 1.453-4.662], 1.54-fold higher risk of a low/high frequency ratio >3.1 [95%CI: 1.085-2.197].
Conclusions:
As a simple screening test, subjective AA measurement can predict important heart aging parameters, including diastolic dysfunction.
Clinicaltrials.Gov Registry No:
NCT04362215.
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