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Contemporary survival trends and aetiological characterization in non-ischaemic dilated cardiomyopathy

Marco Merlo1, Antonio Cannatà1,2, Carola Pio Loco1

  • 1Cardiovascular Department, Centre for Diagnosis and Management of Cardiomyopathies, Azienda Sanitaria Universitaria Integrata di Trieste (ASUITS), University of Trieste, Trieste, Italy.

European Journal of Heart Failure
|May 27, 2020
PubMed

Insights

Survival trends in dilated cardiomyopathy (DCM) have significantly improved, with fewer cardiovascular events. Identifying the cause of DCM may help predict patient outcomes.

Area of Science:

  • Cardiology
  • Heart Disease Research
  • Clinical Outcomes

Background:

  • Contemporary survival trends in dilated cardiomyopathy (DCM) remain largely unknown.
  • Understanding these trends is crucial for improving patient management and outcomes.

Purpose of the Study:

  • To investigate clinical descriptors and survival trends in DCM patients.
  • To evaluate the prognostic impact of aetiological characterization in DCM.

Main Methods:

  • Consecutive enrollment of DCM patients into four enrollment periods (1978-2015).
  • Analysis of clinical characteristics, survival data, and aetiological factors.
  • Competing risk and multivariable analyses were performed.

Main Results:

  • Despite older age in recent cohorts, baseline characteristics improved, indicating earlier diagnosis.
  • Annual incidence of mortality, heart transplantation, and VAD implantation significantly decreased over time.
  • The latest enrollment period was independently associated with reduced mortality and adverse cardiovascular events.

Conclusions:

  • Survival in DCM has significantly improved, primarily due to a reduction in cardiovascular events.
  • Aetiological characterization of DCM is important for patient prognostication.
Abstract

Keywords:
Contemporary survivalDilated cardiomyopathyHeart failureLong-term prognosis

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