Can ¹⁸F-NaF PET/CT before Autologous Stem Cell Transplantation Predict Survival in Multiple Myeloma?

There is an unmet need for positron emission tomography (PET) radiotracers that can image bone disease in multiple myeloma (MM) in a more sensitive and specific way than the widely used ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG). Sodium fluoride (¹⁸F-NaF) is a highly sensitive tracer of bone reconstruction, evolving as an important imaging agent for the assessment of malignant bone diseases. We attempted to investigate for the first time the prognostic significance of ¹⁸F-NaF PET/CT in newly diagnosed, symptomatic MM patients planned for autologous stem cell transplantation (ASCT). Forty-seven patients underwent dynamic and static PET/CT with ¹⁸F-NaF before treatment. After correlation with the respective findings on CT and ¹⁸F-FDG PET/CT that served as reference, the ¹⁸F-NaF PET findings were compared with established factors of high-risk disease, like cytogenetic abnormalities as well as bone marrow plasma cell infiltration rate. Furthermore, the impact of ¹⁸F-NaF PET/CT on progression-free survival (PFS) was analyzed. Correlation analysis revealed a moderate, significant correlation of the ¹⁸F-NaF parameters SUV_average and K₁ in reference tissue with bone marrow plasma cell infiltration rate. However, no significant correlation was observed regarding all other ¹⁸F-NaF PET parameters. Survival analysis revealed that patients with a pathologic ¹⁸F-NaF PET/CT have a shorter PFS (median = 36.2 months) than those with a physiologic scan (median = 55.6 months) (p = 0.02). Nevertheless, no quantitative ¹⁸F-NaF parameter could be shown to adversely affect PFS. In contrast, the respective analysis for quantitative dynamic ¹⁸F-FDG PET/CT revealed that the parameters SUV_max, fractional blood volume (V_B), k₃ and influx from reference tissue as well as SUV_average from MM lesions had a significant negative impact on patient survival. The herein presented findings highlight the rather limited role of ¹⁸F-NaF PET/CT as a single PET approach in MM.