Related Experiment Video
Updated: Dec 20, 2025

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
Published on: March 7, 2025
[Immunotherapy with immune checkpoint inhibitor and skin toxicity]
Pierre-François Simand1, Grégoire Berthod2, Laurent Parmentier3
1Service d'oncologie, HUG, 1211 Genève 14.
Abstract:
Dermatologic toxicities appear to be the most prevalent immunotherapy related adverse effects, both with anti-PD-1 and anti-CTLA-4 agents, as well as with the newly developed anti-PD-L1. They occur in more than one-third of the patients treated with immune check point inhibitors, regardless of the cancer being treated. They mainly manifest in the form of self-limiting maculopapular rashes and pruritus. Early recognition and management are essential in order to mitigate the severity of the lesions. A multidisciplinary team is crucial for optimal management.
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