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Tubulointerstitial Nephritis and Uveitis Syndrome: Characterization of Clinical Features
Anjum F Koreishi1, Mei Zhou1, Debra A Goldstein1
1Department of Ophthalmology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Ocular Immunology and Inflammation
|May 29, 2020
Summary
Tubulointerstitial nephritis and uveitis syndrome (TINU) affects all ages, frequently involving posterior eye segments. Most patients require systemic steroids, and many need long-term immunomodulatory therapy for TINU.
Area of Science:
- Ophthalmology
- Nephrology
- Immunology
Background:
- Tubulointerstitial nephritis and uveitis syndrome (TINU) is a rare condition.
- Understanding its clinical spectrum, particularly posterior segment involvement, is crucial for diagnosis and management.
Purpose of the Study:
- To detail the clinical manifestations of TINU patients.
- To emphasize posterior segment ocular findings in TINU.
Main Methods:
- Retrospective chart review of 17 patients diagnosed with TINU.
- Analysis of clinical presentations and treatment outcomes.
Main Results:
- TINU presented across all age groups (7-49 years), with a female predominance (59%).
- Posterior segment findings were common (65%), including disc edema (41%) and macular edema (24%).
- Elevated urine β2-microglobulin confirmed renal involvement; 65% required systemic steroids and 41% needed immunomodulatory therapy.
Conclusions:
- TINU is not limited to specific age groups and commonly affects the posterior eye segment.
- Effective management often involves systemic steroids and potentially long-term immunomodulation.
- Comprehensive funduscopic examination is essential for all TINU patients.
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