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Thiol/disulphide balance in patients with psoriasis
1Department of Dermatology, Faculty of Medicine, Harran University, Şanlıurfa, Turkey.
Postepy Dermatologii I Alergologii
|May 30, 2020
Summary
Psoriasis patients exhibit an altered thiol/disulfide balance, indicating a shift towards disulfide. This finding supports the role of oxidative stress in the pathogenesis of this chronic inflammatory skin disease.
Area of Science:
- Biochemistry
- Dermatology
- Oxidative Stress Research
Background:
- Psoriasis is a prevalent chronic inflammatory skin condition with incompletely understood causes.
- Oxidative stress is increasingly implicated in the pathogenesis of various diseases.
Purpose of the Study:
- To investigate the thiol/disulfide balance in patients with psoriasis.
- To compare thiol/disulfide balance markers between psoriasis patients and healthy controls.
Main Methods:
- Serum samples from 80 psoriasis patients and 80 healthy controls were analyzed.
- A novel automated method was used to measure serum native thiol, disulfide, and total thiol levels.
- Key ratios including disulfide/native thiol and native thiol/total thiol were calculated.
Main Results:
- Psoriasis patients showed significant differences in total thiol, native thiol, and thiol/disulfide ratios compared to controls.
- No significant difference was observed in absolute disulfide levels between groups.
- A correlation was found between disease duration and the disulfide/native thiol ratio.
Conclusions:
- The thiol/disulfide balance is significantly altered in psoriasis, shifting towards disulfide.
- These findings highlight the role of oxidative stress in the etiopathogenesis of psoriasis.
- Thiol/disulfide balance serves as a potential biomarker for oxidative stress in psoriasis.
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