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Limonoids from Cipadessa baccifera
Jin-Hai Yu1, Hua Zhang1, Bin Zhou1
1State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, People's Republic of China.
Eighteen new limonoids were discovered in Cipadessa baccifera leaves. Some compounds demonstrated moderate antimalarial activity, offering potential for new drug development.
Area of Science:
- Natural Product Chemistry
- Medicinal Chemistry
- Organic Chemistry
Background:
- Cipadessa baccifera is a plant known for its diverse chemical constituents.
- Limonoids are a class of terpenoids with a wide range of biological activities.
Purpose of the Study:
- To isolate and characterize new limonoids from Cipadessa baccifera leaves.
- To evaluate the antimalarial potential of the isolated compounds.
Main Methods:
- Spectroscopic data analyses (NMR, MS)
- Single-crystal X-ray diffraction
- Quantum chemistry computational methods
Main Results:
- Eight new methyl angolensates (1-8) and ten new cipadesins (9-18) were isolated.
- Structural elucidation confirmed the configurations at C-6 and C-2'.
- Compounds 1, 5, 6, 7, 11, and 12 exhibited moderate antimalarial activity (IC50: 12-28 μM).
Conclusions:
- Cipadessa baccifera is a rich source of novel limonoids.
- The identified limonoids possess promising antimalarial properties.
- Further investigation into these compounds could lead to new antimalarial drug leads.
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