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Updated: Dec 20, 2025

A Protocol for Computer-Based Protein Structure and Function Prediction
Published on: November 3, 2011
FATCAT 2.0: towards a better understanding of the structural diversity of proteins
Zhanwen Li1, Lukasz Jaroszewski1, Mallika Iyer2
1Division of Biomedical Sciences, University of California Riverside School of Medicine, Riverside, CA 92521, USA.
Abstract:
FATCAT 2.0 server (http://fatcat.godziklab.org/), provides access to a flexible protein structure alignment algorithm developed in our group. In such an alignment, rotations and translations between elements in the structure are allowed to minimize the overall root mean square deviation (RMSD) between the compared structures. This allows to effectively compare protein structures even if they underwent structural rearrangements in different functional forms, different crystallization conditions or as a result of mutations. The major update for the server introduces a new graphical interface, much faster database searches and several new options for visualization of the structural differences between proteins.
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