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Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides
Published on: May 26, 2019
C-H functionalization of quinazolinones by transition metal catalysis
Prasanjit Ghosh1, Bhaskar Ganguly1, Sajal Das1
1Department of Chemistry, University of North Bengal, Darjeeling - 734013, India. sajal.das@hotmail.com.
Abstract:
Quinazolinone and its congeners are ubiquitous structural motifs found in numerous natural products due to their wide applications as anticancer, antiviral, anti-inflammatory, antifolate and antitumor agents etc. Previously, the synthetic community devoted their efforts towards synthetic approaches but recent years have also witnessed an upsurge in the diversification of this scaffold and its applications. Thus, this review (from 2011 to the beginning of 2020) comprehensively focuses on transition metal catalyzed C-H bond functionalization namely arylation, amination, acetoxylation, amidation, alkylation, alkenylation, alkynylation, halogenation, thiolation, trifluoroethylation etc. of quinazolin-4(3H)-one. Additionally, we also briefly elucidate the plausible mechanistic pathways, scope and limitations.
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