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Updated: Sep 14, 2025

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Site-selective C(sp3)-H amination of (het)aryl acetic acid derivatives under copper(II) catalysis
Arun Kumar Hajra1,2, Prasanjit Ghosh2, Chandreyee Roy1
1TCG Life Sciences Pvt. Ltd., BN-7, Salt Lake City, Kolkata-700091, India. mrinal.kundu@tcgls.com.
Abstract:
A ubiquitous copper(II) catalyzed cross-dehydrogenative (CDC) process of (Het)arylacetamide derivatives employing free cyclic/acyclic secondary amines with the aid of 8-aminoimidazo[1,2-a pyridine] (8-AIP) as a bidentate chelating auxiliary has been successfully developed. This methodology exhibits a broad substrate scope with good functional group compatibility in the presence of air. Furthermore, the synthetic adaptability of this novel protocol is showcased through the post-diversification of synthesized derivatives.
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