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Cellular Affinity of Particle-Stabilized Emulsion to Boost Antigen Internalization
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Cellular Uptake of Active Particles.

Pengyu Chen1, Ziyang Xu1, Guolong Zhu1

  • 1State Key Laboratory of Chemical Engineering, Department of Chemical Engineering, Tsinghua University, Beijing 100084, China.

Physical Review Letters
|May 30, 2020
PubMed
Summary
This summary is machine-generated.

Cellular uptake of active particles is key for biomedical tech. We found tilted active particles show non-monotonic uptake, unlike normal particles, due to adhesion and kinetic energy interplay.

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Area of Science:

  • Biomedical engineering
  • Soft matter physics
  • Cellular biophysics

Background:

  • Active particles offer revolutionary potential in biomedical applications.
  • Understanding the physical mechanisms of active particle cellular uptake in nonequilibrium states is crucial but limited.

Purpose of the Study:

  • To elucidate the physical criteria governing cellular uptake of active particles.
  • To investigate the influence of particle activity and orientation on uptake efficiency.

Main Methods:

  • Brownian dynamics simulations were employed to model particle behavior.
  • Theoretical analysis was conducted to derive uptake criteria and understand underlying physics.

Main Results:

  • Uptake efficiency for tilted active particles exhibits a non-monotonic dependence on activity, contrasting with monotonic uptake for normally oriented particles.
  • This non-monotonic behavior arises from the interplay between membrane adhesion energy and particle kinetic energy.

Conclusions:

  • A theoretical model was developed, accurately reproducing the non-monotonic uptake feature.
  • Findings provide insights into activity-mediated cellular interactions and internalization of active colloids.