Cardiovascular ochronosis

Area of Science:

• Cardiovascular Medicine
• Pathology
• Medical History

Background:

• Ochronosis is a rare condition characterized by the deposition of ochronotic pigment.
• This pigment can affect various tissues, including cardiovascular structures.
• Understanding ochronosis is crucial for diagnosing and managing affected patients.

Observation:

• This review synthesizes findings from 66 previously reported case reports.
• Ochronotic pigment was identified in cardiovascular structures during necropsy or surgical excision.
• Two illustrative cases involving excised aortic valves and aorta with black pigment are presented, likely secondary ochronosis.

Findings:

• The presence of ochronotic pigment in cardiac valves, aorta, and arteries is documented.
• Secondary ochronosis is suggested in the presented patient cases.
• The review consolidates existing literature on cardiovascular manifestations of ochronosis.

Implications:

• Highlights the importance of recognizing ochronotic pigment in cardiovascular tissues.
• Provides a historical perspective on the study of ochronosis.
• Informs clinicians about the potential cardiovascular involvement in ochronosis.