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Updated: Dec 20, 2025
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Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
Published on: August 14, 2019
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Himalaflavone A-E, five new flavonoids from Oxybaphus himalaicus
Xuanning Long1, Fancheng Meng1, Shenyue Qu1
1Key Laboratory on Luminescence and Real-Time Analytical Chemistry (Ministry of Education), College of Pharmaceutical Sciences, Southwest University, Chongqing, P.R. China.
Natural Product Research
|June 2, 2020
Summary
Researchers isolated new and known flavonoids from Oxybaphus himalaicus roots. Compound 11 showed significant cytotoxic activity against lung and liver cancer cells in vitro.
Area of Science:
- Natural Product Chemistry
- Pharmacology
Background:
- The roots of Oxybaphus himalaicus are a potential source of bioactive compounds.
- Flavonoids are a class of natural products with diverse biological activities.
Purpose of the Study:
- To isolate and characterize chemical constituents from Oxybaphus himalaicus roots.
- To evaluate the in vitro cytotoxic activities of the isolated compounds against cancer cell lines.
Main Methods:
- Isolation of compounds using chromatographic techniques.
- Structure elucidation using Nuclear Magnetic Resonance (NMR), High-Resolution Electrospray Ionization Mass Spectrometry (HRESIMS), and Electronic Circular Dichroism (ECD).
- Cytotoxicity assays against human lung carcinoma A549 and human hepatocellular carcinoma HepG2 cells.
Main Results:
- Five new flavonoids (1-5) and ten known flavonoids (6-15) were isolated.
- Compound 11 exhibited potent cytotoxic activity with IC50 values of 19.47 ± 0.28 μM against A549 and 52.6 ± 0.38 μM against HepG2 cells.
- Other isolated compounds also showed varying degrees of cytotoxic effects.
Conclusions:
- Oxybaphus himalaicus roots contain a rich source of flavonoids with significant cytotoxic potential.
- Compound 11 is a promising candidate for further investigation as an anticancer agent.
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