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Updated: Dec 20, 2025
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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
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Diffuse bronchiectasis and airflow obstruction in granulomatosis with polyangiitis.
T Barba1, C Khouatra2, J Traclet J1,2
1Hospices Civils de Lyon, Hôpital Edouard Herriot, Service de Médecine Interne, Lyon, France.
Summary
Granulomatosis with Polyangiitis (GPA) typically causes lung nodes and bleeding. This study highlights unusual cases where GPA led to diffuse bronchiectasis and independent airflow obstruction, causing respiratory issues and infections.
Area of Science:
- Pulmonary Medicine
- Rheumatology
- Infectious Disease
Background:
- Granulomatosis with Polyangiitis (GPA) characteristically presents with parenchymal lung nodes and intra-alveolar hemorrhage.
- Diffuse bronchiectasis and airflow obstruction are uncommon pulmonary manifestations in GPA patients.
Observation:
- This report details three patients diagnosed with GPA who subsequently developed diffuse bronchiectasis during their disease course.
- These patients experienced airflow obstruction that appeared to progress independently of the underlying GPA.
Findings:
- The independent progression of airflow obstruction led to respiratory insufficiency in the observed patients.
- The presence of bronchiectasis increased susceptibility to opportunistic infections, notably atypical mycobacteria.
Implications:
- This case series suggests that diffuse bronchiectasis is a potential, albeit unusual, complication of GPA.
- Clinicians should be vigilant for the development of bronchiectasis and subsequent complications in GPA patients, including opportunistic infections and respiratory failure.
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