Bioactive peptides from beans with the potential to decrease the risk of developing noncommunicable chronic diseases.

Area of Science:

• Nutritional biochemistry
• Bioinformatics
• Food science

Background:

• Peptides derived from food proteins, especially beans, exhibit therapeutic potential for noncommunicable chronic diseases (NCDs).
• Hydrolysis of food proteins yields peptides with diverse structures and biological activities.
• Storage globulin proteins are abundant in legumes like beans.

Purpose of the Study:

• To computationally identify potential bioactive peptides from storage globulin proteins of four bean species: *Phaseolus vulgaris*, *Vigna angularis*, *Vigna radiata*, and *Vigna unguiculata*.
• To review existing research on the in vitro bioactivity of bean-derived peptides.

Main Methods:

• In silico analysis using UniProtKB, BIOPEP, and PeptideRanker databases.
• Literature review of in vitro studies on bean-derived bioactive peptides.

Main Results:

• The study identified a high frequency of bioactive fragments associated with dipeptidyl peptidase-IV (DPP-IV) inhibition across all studied bean species.
• Angiotensin-converting enzyme (ACE) inhibition and antioxidant activity were also frequently identified bioactive properties.
• DPP-IV and ACE inhibition are key targets for managing type 2 diabetes mellitus (T2DM) and hypertension, respectively.

Conclusions:

• Storage globulin proteins from *Phaseolus vulgaris*, *Vigna angularis*, *Vigna radiata*, and *Vigna unguiculata* are promising sources of bioactive peptides.
• Identified peptides show potential for therapeutic applications in managing T2DM, hypertension, and oxidative stress-related chronic diseases.
• In silico and in vitro approaches are valuable for discovering novel food-derived bioactive peptides.