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Bioactive Peptides from Corn (<i>Zea mays</i> L.) with the Potential to Decrease the Risk of Developing Non-Communicable Chronic Diseases: In Silico Evaluation.

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Bioactive peptides from beans with the potential to decrease the risk of developing noncommunicable chronic diseases.

Bianca de Fátima Garcia1, Márcio de Barros1, Thaís de Souza Rocha1

  • 1Department of Food Science and Technology, State University of Londrina - UEL, Londrina, PR, Brazil.

Critical Reviews in Food Science and Nutrition
|June 2, 2020
PubMed
Summary
This summary is machine-generated.

Bean protein-derived peptides show potential for treating chronic diseases. Computational analysis identified bioactive fragments in common beans, particularly those inhibiting enzymes linked to type 2 diabetes and hypertension, and possessing antioxidant properties.

Keywords:
Arterial hypertensionbioinformaticsproteinpublic healthtype 2 diabetes mellitus

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Area of Science:

  • Nutritional biochemistry
  • Bioinformatics
  • Food science

Background:

  • Peptides derived from food proteins, especially beans, exhibit therapeutic potential for noncommunicable chronic diseases (NCDs).
  • Hydrolysis of food proteins yields peptides with diverse structures and biological activities.
  • Storage globulin proteins are abundant in legumes like beans.

Purpose of the Study:

  • To computationally identify potential bioactive peptides from storage globulin proteins of four bean species: *Phaseolus vulgaris*, *Vigna angularis*, *Vigna radiata*, and *Vigna unguiculata*.
  • To review existing research on the in vitro bioactivity of bean-derived peptides.

Main Methods:

  • In silico analysis using UniProtKB, BIOPEP, and PeptideRanker databases.
  • Literature review of in vitro studies on bean-derived bioactive peptides.

Main Results:

  • The study identified a high frequency of bioactive fragments associated with dipeptidyl peptidase-IV (DPP-IV) inhibition across all studied bean species.
  • Angiotensin-converting enzyme (ACE) inhibition and antioxidant activity were also frequently identified bioactive properties.
  • DPP-IV and ACE inhibition are key targets for managing type 2 diabetes mellitus (T2DM) and hypertension, respectively.

Conclusions:

  • Storage globulin proteins from *Phaseolus vulgaris*, *Vigna angularis*, *Vigna radiata*, and *Vigna unguiculata* are promising sources of bioactive peptides.
  • Identified peptides show potential for therapeutic applications in managing T2DM, hypertension, and oxidative stress-related chronic diseases.
  • In silico and in vitro approaches are valuable for discovering novel food-derived bioactive peptides.