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Noncovalent Attractions in Biomolecules02:35

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Interactions between Biomolecules and Zwitterionic Moieties: A Review.

Amir Erfani1, Joshua Seaberg1, Clint Philip Aichele1

  • 1School of Chemical Engineering, Oklahoma State University, Stillwater, Oklahoma 74078, United States.

Biomacromolecules
|June 2, 2020
PubMed
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Zwitterionic materials offer superior biocompatibility by preventing protein adsorption, enabling advanced biomedical applications like targeted drug delivery. Further research into biomolecule interactions will enhance their use in medicine.

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Surface Chemistry

Background:

  • Zwitterionic moieties are recognized for their superhydrophilic nature, crucial for preventing nonspecific protein adsorption.
  • Their biocompatibility makes them ideal for various biomedical applications, including drug delivery and implantable material modification.

Purpose of the Study:

  • To review recent advancements in understanding biomolecule-zwitterion interactions.
  • To explore the solution behavior and molecular interactions of zwitterions and zwitterionic polymers with biomolecules.
  • To discuss the in vivo implications and potential for targeted delivery of therapeutic agents.

Main Methods:

  • Focus on experimental and theoretical studies.
  • Analysis of solution behavior of zwitterions and zwitterionic polymers.
  • Review of biomolecule interactions with zwitterionic materials.

Main Results:

  • Zwitterionic materials demonstrate significant potential in preventing protein adsorption.
  • Diverse architectures (nanoparticles, hydrogels, etc.) utilize zwitterionic properties.
  • Understanding molecular interactions is key to optimizing biomedical applications.

Conclusions:

  • Zwitterionic moieties are vital for developing advanced biocompatible materials.
  • Further research is needed to bridge knowledge gaps for enhanced in vivo applications.
  • Zwitterions hold promise for targeted delivery of proteins, genes, and small molecules.