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Biomarkers of doping: uses, discovery and validation
Reid Aikin1, Norbert Baume1, Tristan Equey1
1World Anti-Doping Agency, 800 Rue du Square-Victoria Suite 1700, Montreal, QC H4Z 1B7, Canada.
Bioanalysis
|June 2, 2020
Summary
Discovering new doping biomarkers is crucial for improving athlete drug detection and deterring doping. This study highlights the need for better study designs and analytical methods to find novel doping biomarkers effectively.
Area of Science:
- Sports Science
- Biomarker Discovery
- Anti-Doping Research
Background:
- Biomarkers of doping are essential for detecting prohibited substance use in athletes.
- Current anti-doping efforts have focused on detecting metabolites, with less success in developing new biomarkers.
- Improved detection methods are needed to enhance anti-doping outcomes and influence athlete behavior.
Purpose of the Study:
- To emphasize the importance of novel biomarker discovery in anti-doping.
- To outline critical considerations for developing new doping biomarkers.
- To highlight the potential for advancing anti-doping strategies through biomarker research.
Main Methods:
- Review of current anti-doping strategies and biomarker research.
- Discussion of study designs and analytical approaches for biomarker discovery.
- Analysis of challenges and opportunities in developing novel doping biomarkers.
Main Results:
- The field of anti-doping is well-positioned for significant biomarker discovery.
- Successful translation into routine analysis requires careful selection of study designs and analytical methods.
- There is a recognized need for new biomarkers beyond the detection of prohibited metabolites.
Conclusions:
- Developing novel biomarkers of doping is a critical objective for the anti-doping community.
- Strategic implementation of advanced study designs and analytical techniques is key to success.
- Further research into novel biomarkers will strengthen anti-doping measures and promote fair play.
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