Related Experiment Video
Updated: Dec 20, 2025

Generic Protocol for Optimization of Heterologous Protein Production Using Automated Microbioreactor Technology
Published on: December 15, 2017
The Role of Reaction Engineering in Bioprocess Development
1Department of Chemistry, Industrial and Applied Chemistry, University of Rostock, Albert-Einstein-Str. 3A, 18059 Rostock, Germany; Department Life, Light and Matter, University of Rostock, 18051 Rostock, Germany;,
Abstract:
This short review highlights the role of reaction engineering as a tool for bioprocess development. Selected examples are discussed that demonstrate the need to understand thermodynamic and kinetic properties of the reaction system in order to identify potential bottlenecks. For coupled enzyme systems and reaction cascades modelling as well as selection of suitable reactor configurations is discussed. For the problem of overcoming product inhibition examples are given, followed by selected examples for in situ product removal. Finally, two reactor concepts for oxidation reactions requiring oxygen are briefly presented.
Related Concept Videos
Introduction to Chemical Reactions
Phase I Reactions: Reductive Reactions
Predicting Reaction Outcomes
Drug Metabolism: Phase I Reactions
Phase I Reactions: Hydrolytic Reactions
An important hydrolytic reaction is ester hydrolysis. Ester bonds, often found in prodrugs, are broken down, increasing the solubility of drugs like aspirin and lidocaine for more straightforward elimination. Amide hydrolysis is another critical reaction, targeting amide bonds prevalent...
Biosynthesis in Bacteria

