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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Tumor Immunotherapy01:27

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Treatment Resistant Cancers

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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Related Experiment Video

Updated: Dec 20, 2025

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine
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Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

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Adjuvant Therapy for Cutaneous Melanoma.

Darryl Schuitevoerder1, Charles C Vining1, Jennifer Tseng1

  • 1Department of Surgery, University of Chicago, 5841 South Maryland Avenue # MC5094, Chicago, IL 60637, USA.

Surgical Oncology Clinics of North America
|June 3, 2020
PubMed
Summary

Adjuvant therapy, including immunotherapy and targeted therapy, shows strong support for high-risk cutaneous melanoma patients. These treatments aim to prevent disease recurrence or metastasis.

Keywords:
Adjuvant therapyBRAFImmunotherapyMEKMelanomaTargeted therapy

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Area of Science:

  • Oncology
  • Dermatology
  • Medical Therapeutics

Background:

  • Cutaneous melanoma is a significant skin cancer with a risk of recurrence and metastasis.
  • Adjuvant therapy aims to reduce the risk of cancer returning after initial treatment.

Purpose of the Study:

  • To review current data supporting adjuvant therapy for cutaneous melanoma.
  • To highlight the role of novel immunotherapies and targeted therapies.

Main Methods:

  • Review of current clinical data and research.
  • Analysis of evidence for immunotherapy and targeted therapy efficacy.

Main Results:

  • Strong data support the use of novel immunotherapy agents in the adjuvant setting.
  • Targeted therapies also demonstrate efficacy in preventing recurrence.
  • These treatments are beneficial for patients with high-risk melanoma.

Conclusions:

  • Adjuvant immunotherapy and targeted therapy are valuable options for high-risk cutaneous melanoma.
  • These therapies represent a significant advancement in melanoma treatment.
  • Further research continues to refine adjuvant treatment strategies.