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Updated: Dec 20, 2025

Multiplexed Barcoding Image Analysis for Immunoprofiling and Spatial Mapping Characterization in the Single-Cell Analysis of Paraffin Tissue Samples

Multiplexed Barcoding Image Analysis for Immunoprofiling and Spatial Mapping Characterization in the Single-Cell Analysis of Paraffin Tissue Samples

Published on: April 7, 2023

Multiplexed SERS Barcodes for Anti-Counterfeiting.

Yusai Zhou¹, Gui Zhao¹, Jingming Bian¹

¹Institute of Advanced Synthesis and School of Chemistry and Molecular Engineering, Jiangsu National Synergetic Innovation Center for Advanced Materials, Nanjing Tech University, Nanjing 211816, Jiangsu, P. R. China.

ACS Applied Materials & Interfaces

|June 3, 2020

Summary

This summary is machine-generated.

This study introduces a novel Surface-Enhanced Raman Spectroscopy (SERS) system for signature anti-counterfeiting. The advanced SERS inks offer enhanced security and easy verification via smartphone apps.

Keywords:

(Au-aggregate)@Ag@PSPAA nanostructures SERS anti-counterfeiting mixed ligands signatures

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Last Updated: Dec 20, 2025

Multiplexed Barcoding Image Analysis for Immunoprofiling and Spatial Mapping Characterization in the Single-Cell Analysis of Paraffin Tissue Samples

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Published on: January 6, 2016

Area of Science:

Materials Science
Analytical Chemistry
Nanotechnology

Background:

Forged signatures pose a significant threat to personal identity authenticity.
Existing anti-counterfeiting methods often lack robust security features and ease of verification.

Purpose of the Study:

To design an effective Surface-Enhanced Raman Spectroscopy (SERS) anti-counterfeiting system for personal signatures.
To enhance Raman spectral complexity and coding capacity for improved security.
To develop stable and highly sensitive SERS inks for practical application.

Main Methods:

Utilized mixed ligands to create complex Raman spectra from five distinct ligands, achieving fourteen unique combinations.
Synthesized a (Au-aggregate)@Ag@PSPAA nanostructure to enhance SERS intensity and stability.
Developed SERS inks incorporating the nanostructure and applied them to signature anti-counterfeiting.

Main Results:

Achieved significant expansion of coding capacity through ligand combinations.
Demonstrated excellent SERS detection performance due to enhanced signal intensity and stability.
Successfully converted SERS spectra into barcodes detectable by a smartphone application.

Conclusions:

The developed SERS system offers a powerful and practical solution for signature anti-counterfeiting.
Integration of mixed ligands and advanced nanostructures significantly improves security and detection capabilities.
This work advances the practical application of SERS technology in combating identity fraud.