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Related Experiment Video

Updated: Dec 20, 2025

Updated Protocol for the Assembly and Use of the Minibioreactor Array (MBRA)

Updated Protocol for the Assembly and Use of the Minibioreactor Array (MBRA)

Published on: September 5, 2025

A BRAF new world.

Daniele Frisone¹, Alex Friedlaender², Umberto Malapelle³

¹IOSI - Oncology Institute of Southern Switzerland, Switzerland.

Critical Reviews in Oncology/Hematology

|June 3, 2020

Summary

This summary is machine-generated.

BRAF mutations in non-small-cell lung cancer (NSCLC) are diverse, with non-V600E types lacking targeted therapies. This review updates knowledge on BRAF mutations in NSCLC, highlighting therapeutic disparities.

Keywords:

BRAF NSCLC Target therapy

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Area of Science:

Oncology
Genetics
Molecular Biology

Background:

BRAF mutations are rare but targetable in non-small-cell lung cancer (NSCLC).
BRAF mutations in lung adenocarcinoma exhibit significant diversity beyond single point mutations.
A critical distinction exists between V600E and non-V600E BRAF mutations, impacting clinical and therapeutic outcomes.

Purpose of the Study:

To review current literature on BRAF mutations in NSCLC.
To provide an updated scientific understanding of the various types of BRAF mutations in NSCLC.
To highlight the clinical and therapeutic implications of different BRAF mutations, particularly non-V600E variants.

Main Methods:

Literature review of scientific publications.
Analysis of emerging evidence on BRAF mutation prevalence and characteristics in NSCLC.
Synthesis of current knowledge regarding BRAF V600E versus non-V600E mutations.

Main Results:

BRAF mutations in NSCLC, especially lung adenocarcinoma, are more varied than previously thought.
Non-V600E BRAF mutations are as common as V600E mutations in NSCLC.
Non-V600E BRAF mutations currently lack established targeted therapeutic options.

Conclusions:

Understanding the heterogeneity of BRAF mutations in NSCLC is crucial for personalized treatment strategies.
The prevalence and clinical significance of non-V600E BRAF mutations warrant further investigation.
Development of targeted therapies for non-V600E BRAF mutations is a critical unmet need in NSCLC treatment.