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Bio-inspired Polydopamine Surface Modification of Nanodiamonds and Its Reduction of Silver Nanoparticles
Published on: November 14, 2018
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Surface functionalization of nanodiamonds for biomedical applications.
Dhruvil Hiteshkumar Jariwala1, Dhrumi Patel1, Sarika Wairkar1
1Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM's NMIMS, V.L. Mehta Road, Vile Parle (W), Mumbai, Maharashtra 400056, India.
Summary
Surface functionalization of nanodiamonds (NDs) improves their safety and biocompatibility for biomedical uses. This process enhances their properties for applications like diagnosis and targeted drug delivery.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Nanodiamonds (NDs) are carbon nanomaterials with versatile surface chemistry.
- NDs are synthesized via detonation, followed by purification and surface modification.
- Surface functionalization is crucial for enhancing NDs' safety, biocompatibility, and reducing toxicity.
Purpose of the Study:
- To review surface functionalization methods for nanodiamonds.
- To explore the biomedical applications of functionalized nanodiamonds.
- To highlight the benefits of surface functionalization for NDs' physicochemical properties.
Main Methods:
- Surface homogenization of NDs.
- Attachment of ligands via covalent and non-covalent methods.
- Functionalization with various groups, biomolecules, or polymers.
Main Results:
- Functionalization enhances ND hydrophobicity and reduces surface charge.
- Improved surface chemistry of NDs is achieved.
- Enhanced safety and biocompatibility of NDs.
Conclusions:
- Surface functionalization significantly improves nanodiamond properties.
- Functionalized NDs show potential in diagnosis and targeted drug delivery.
- Tailoring ND surface chemistry is key for advanced biomedical applications.
