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Etiologies of olfactory dysfunction in a pediatric population: based on a retrospective analysis of data from an
Valentin Alexander Schriever1, Thomas Hummel2
1Abteilung Neuropädiatrie an der Klinik und Poliklinik für Kinder- und Jugendmedizin, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Fetscherstrasse 74, 01307, Dresden, Germany. valentin.schriever@uniklinikum-dresden.de.
Insights
Two-thirds of childhood olfactory dysfunction is congenital, with acquired causes increasing with age. Etiologies differ significantly between pediatric and adult populations, highlighting age-related changes in smell loss.
Area of Science:
- Otolaryngology
- Pediatric Medicine
- Neuroscience
Background:
- Olfactory dysfunction is less common in children than adults, but its causes in pediatric populations are not well understood.
- Understanding the epidemiology of smell dysfunction in children is crucial for accurate diagnosis and treatment.
Purpose of the Study:
- To describe the epidemiology of olfactory dysfunction in a pediatric population.
- To compare the distribution of smell loss etiologies in children versus adults.
Main Methods:
- Retrospective analysis of patients consulting a smell and taste clinic from 2000 to 2017.
- Examination of the frequency of major causes of olfactory dysfunction, with a specific focus on pediatric cases.
Main Results:
- 164 children were included in the analysis of 7153 patients.
- Congenital olfactory dysfunction (67%) and head trauma (12%) were the most common causes in children.
- Sinonasal disorders and upper airway infections accounted for only 6% of pediatric olfactory dysfunction, contrasting with adult populations.
Conclusions:
- Approximately two-thirds of olfactory dysfunction in children is congenital, with one-third being acquired.
- The frequency of etiologies for olfactory dysfunction significantly changes from childhood to adulthood.
Purpose:
Although the prevalence of olfactory dysfunction in children is thought to be lower compared to adults, little is known about the actual frequency of etiologies of smell dysfunction in children. Aim of the study was (i) to describe the epidemiology of olfactory dysfunction in a pediatric population and (ii) to compare the distribution of etiologies to adults.
Material And Methods:
Data of patients consulting a smell and taste clinic between 2000 and 2017 were retrospectively analyzed. Frequency of major causes of olfactory dysfunction was examined with a focus on the pediatric population.
Results:
A total of 7153 patients (164 children) were included in the analysis. Most children presented with congenital olfactory dysfunction (67%), or head-trauma (12%). In contrast, the cumulative frequency of olfactory loss associated with sinonasal disorders or acute infections of the upper airways was 6%. The frequency of etiologies of olfactory dysfunction changed with age: While the frequency of patients with congenital anosmia decreased, the frequency of causes related to infections of the upper respiratory tract and idiopathic causes increased.
Conclusion:
About 2/3 of olfactory dysfunction in children are congenital while 1/3 is acquired. The frequency of etiologies causing olfactory dysfunction change significantly from children to an adult population.
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