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Updated: Dec 19, 2025

Imaging Cell Viability on Non-transparent Scaffolds — Using the Example of a Novel Knitted Titanium Implant
Published on: September 7, 2016
Functional State of Mesenchymal Stem Cells upon Exposure to Bioactive Coatings on Titanium Alloys
N G Plekhova1, I N Lyapun2, E I Drobot2
1Central Research Laboratory, Pacific State Medical University, the Ministry of Health of the Russian Federation, Vladivostok, Russia. pl_nat@hotmail.com.
Abstract:
Bioactive coatings on implants affect osteogenic differentiation of mesenchymal stem cells (MSC). We studied the morphofunctional state of bone marrow MSC cultured on the surface of calcium phosphate coatings on titanium formed by plasma electrolytic oxidation (PEO). The biocompatible properties of the coatings manifested in the absence of the cytotoxic effect on cells. High expression of receptors (CD90, CD29, and CD106), enhanced synthesis of osteocalcin and osteopontin, and changes in surface architectonics of MSC adherent to the samples confirmed osteoinductive properties of the calcium phosphate PEO coating.

