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Atrial angiotensin-(1-12)/chymase expression data in patient of heart diseases

Hao Wang1,2, Jasmina Varagic3,4,5, Sayaka Nagata3

  • 1Department of Anesthesiology, Wake Forest School of Medicine, Winston-Salem, NC, USA.

Data in Brief
|June 4, 2020
PubMed

Insights

The angiotensin-(1-12) [Ang-(1-12)]/chymase axis is more active in the left atrium than the right. This axis was further investigated in relation to stroke, heart failure, and atrial fibrillation.

Area of Science:

  • Cardiovascular Biology
  • Biochemistry
  • Human Physiology

Background:

  • The renin-angiotensin system plays a crucial role in cardiovascular homeostasis.
  • Angiotensin-(1-12) [Ang-(1-12)] is a precursor to Angiotensin II, a key effector peptide.
  • Chymase is a serine protease that can generate Angiotensin II from Ang-(1-12).

Purpose of the Study:

  • To investigate the differential expression of the Ang-(1-12)/chymase axis in human atrial tissue.
  • To compare Ang-(1-12) and chymase levels in left versus right atria.
  • To explore the association of atrial Ang-(1-12) and chymase expression with clinical conditions like stroke, heart failure, and atrial fibrillation.

Main Methods:

  • Analysis of chymase gene transcripts and activity in human atrial tissue.
  • Measurement of immunoreactive Ang-(1-12) expression levels.
  • Comparison of these markers between left and right atrial samples.
  • Correlation with echocardiographic data and patient clinical history (stroke, heart failure, postoperative atrial fibrillation).

Main Results:

  • Chymase gene transcripts, activity, and Ang-(1-12) expression were significantly higher in the left atrium compared to the right atrium.
  • These differences persisted irrespective of underlying cardiac disease.
  • Elevated left atrial chymase and Ang-(1-12) levels were observed in patients with specific clinical conditions, warranting further investigation.

Conclusions:

  • The human left atrium exhibits higher expression and activity of the Ang-(1-12)/chymase axis compared to the right atrium.
  • This axis may be implicated in the pathophysiology of conditions such as stroke, heart failure, and atrial fibrillation.
  • Further research is needed to elucidate the precise role of this axis in cardiovascular disease.

Keywords:
angiotensin IIangiotensin-(1-12)atriachymaseheart diseasehuman

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