Non-invasive electroencephalographical (EEG) recording system in awake monkeys
Tomoya Nakamura1,2, Trong Ha Dinh1, Makoto Asai3
1System Emotional Science, Faculty of Medicine, University of Toyama, Toyama 930-0194, Japan.
Heliyon
|June 4, 2020
Summary
A new head-holding system enables precise scalp electroencephalography (EEG) recording in awake monkeys. This advancement aids in studying psychiatric disorders and developing new treatments by capturing auditory evoked potentials (AEPs).
Area of Science:
- Neuroscience
- Primate Research
- Biomarker Discovery
Background:
- Electroencephalography (EEG) parameters serve as biomarkers for psychiatric disorders in humans.
- Non-human primate EEG studies are crucial for understanding human psychiatric conditions and developing therapeutics.
Purpose of the Study:
- To develop and validate an improved non-invasive head-holding system for scalp EEG recording in awake monkeys.
- To enable electrode placement comparable to human positioning and auditory stimulus presentation.
Main Methods:
- An enhanced non-invasive head-holding system with face masks was designed for awake monkeys.
- The system allows open access to the top, sides, and rear of the head for EEG electrode attachment and auditory stimulation.
- Auditory evoked potentials (AEPs) were recorded using sensory gating and oddball paradigms.
Main Results:
- The system facilitated scalp EEG recording in awake monkeys with electrode placement similar to human studies.
- Auditory evoked potentials (AEPs) were successfully recorded and found comparable to human clinical data.
- The system demonstrated efficacy in auditory sensory gating and oddball paradigms.
Conclusions:
- The developed head-holding system is effective for EEG recording in awake monkeys.
- This system has potential applications in eye-tracking and chronic intra-cerebral recording experiments.
- It supports the use of non-human primates as models for psychiatric disorder research.
