Related Experiment Video

Updated: Dec 19, 2025

Come to the Light Side: In Vivo Monitoring of Pseudomonas aeruginosa Biofilm Infections in Chronic Wounds in a Diabetic Hairless Murine Model
09:15

Come to the Light Side: In Vivo Monitoring of Pseudomonas aeruginosa Biofilm Infections in Chronic Wounds in a Diabetic Hairless Murine Model

Published on: October 10, 2017

13.9K

A Young Diabetic Patient With Sepsis After Gardening

Nataly Camargo1,2, Giovanna K Casadiego1, Dinno A Fernandez2

  • 1Universidad Libre, Barranquilla, Colombia.

Open Forum Infectious Diseases
|June 5, 2020
PubMed

Insights

We describe a case of melioidosis, a serious infection caused by Burkholderia pseudomallei, in a young diabetic patient. The study includes genomic analysis of the bacterial isolate, providing insights into this rare disease.

Area of Science:

  • Infectious Diseases
  • Genomics
  • Microbiology

Background:

  • Melioidosis, caused by Burkholderia pseudomallei, is a serious infectious disease with high morbidity and mortality.
  • It is endemic in Southeast Asia and Australia but increasingly reported globally.
  • Diabetes mellitus is a significant risk factor for melioidosis.

Observation:

  • A young diabetic patient presented with soft tissue infection, sepsis, and bacteremia.
  • The causative agent was identified as Burkholderia pseudomallei.
  • The specific bacterial isolate was designated COL-5428.

Findings:

  • Genomic characterization of the Burkholderia pseudomallei isolate (COL-5428) was performed.
  • This analysis provides detailed genetic information about the pathogen.
  • Understanding the genomic features can aid in tracking and understanding disease transmission.

Implications:

  • This case highlights the importance of considering melioidosis in endemic and non-endemic regions, especially in diabetic patients.
  • Genomic data can enhance our understanding of Burkholderia pseudomallei virulence and evolution.
  • Further research into genomic epidemiology is crucial for public health strategies against melioidosis.

More Related Videos

Improving IV Insulin Administration in a Community Hospital12:08

Improving IV Insulin Administration in a Community Hospital

Published on: June 11, 2012

19.2K

Related Concept Videos

Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
1.9K
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
4.2K
Hypoglycemia and Glucagon01:15

Hypoglycemia and Glucagon

Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
706
SBAR II: Application of SBAR01:14

SBAR II: Application of SBAR

SBAR is an effective communication tool used by healthcare professionals to communicate patient information accurately. SBAR stands for Situation, Background, Assessment, and Recommendation. For a better understanding, an example is given below.
SBAR Report from a Nurse to a Health Care Provider
S: "Hello, Dr. Smith. This is Jane, RN, from the Med Surg unit. I am calling to tell you about Ms. White in Room 210, who is experiencing increased pain and redness at her incision site. Her recent...
5.5K
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
4.7K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
2.9K