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Published on: April 11, 2016
Molecular Profiling of Follicular Variant of Papillary Thyroid Cancer
L V Spirina1,2, S Yu Chizhevskaya3, I V Kondakova3
1Cancer Research Institute, Tomsk National Research Medical Center, Tomsk, Russia. spirinalvl@mail.ru.
Abstract:
The molecular features of the follicular variant of papillary thyroid cancer are closely related to the clinical behavior of the tumor and the prognosis of the disease. BRAF-V600E mutations in patients with a follicular variant of papillary thyroid cancer have not been identified; however, the majority of patients had T3-4N0M0 stage of the disease. Changes in the expression of transcription and growth factors and AKT/m-TOR signaling pathway components were detected. In addition, hyperexpression of m-TOR and 4EBP1 kinases and CAIX enzyme was shown compared to the classical variant of papillary thyroid cancer, where an increase in the nuclear factor NF-κB p65 and c-RAF kinase expression was observed.

