Related Experiment Video
Updated: Jul 3, 2025
07:46
Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation
Published on: April 3, 2017
25.3K
Neuroinflammation in Obese Children
Yu G Samoilova1, M V Matveeva2, L V Spirina1
1Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia.
Bulletin of Experimental Biology and Medicine
|February 10, 2024
Summary
Obese children show increased M2-polarized CD14+CD163+ monocytes, linked to cognitive decline and lower IQ. This suggests a connection between visceral fat, neuroinflammation, and brain function in childhood obesity.
Area of Science:
- Immunology
- Neuroscience
- Pediatrics
Background:
- Obesity is linked to chronic inflammation and neuroinflammation.
- Tissue macrophages in obesity can cross the blood-brain barrier.
Purpose of the Study:
- To analyze the association between CD14+CD163+ monocytes and cognitive functions in obese children.
- To investigate the role of M2-polarized monocytes in childhood obesity and neuroinflammation.
Main Methods:
- Studied 56 obese children and 10 controls.
- Assessed body composition and calculated BMI SDS.
- Quantified CD14+CD163+ monocytes using flow cytometry.
- Evaluated cognitive functions via IQ and Rey test.
Main Results:
- Increased M2-polarized CD14+CD163+ monocytes correlated with obesity severity.
- Higher monocyte levels were found in children with cognitive decline.
- A negative correlation existed between M2 monocytes, IQ, and visceral fat.
Conclusions:
- M2-polarized CD14+CD163+ monocytes are associated with obesity and cognitive deficits in children.
- Peripheral visceral obesity and neuroinflammation play a role in these findings.
