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Direct effects of altered temperature on renal structure and function.

B L Kasiske1, M P O'Donnell, W F Keane

  • 1Department of Medicine, Hennepin County Medical Center, University of Minnesota, Minneapolis.

Renal Physiology and Biochemistry
|January 1, 1988
PubMed
Summary

Elevated temperatures cause significant kidney damage and reduced function in acute renal failure (ARF) models. Lower temperatures protect renal structure and function by preserving ATP levels.

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Area of Science:

  • Nephrology
  • Physiology
  • Biochemistry

Background:

  • Temperature fluctuations are common in acute renal failure (ARF).
  • The impact of temperature on renal function and structure is not well understood.
  • Limited research exists on how altered temperatures affect kidney health during ARF.

Purpose of the Study:

  • To investigate the effects of varying temperatures on kidney structure and function.
  • To determine the relationship between temperature, ATP levels, and renal damage in ARF.
  • To explore the underlying mechanisms of temperature-induced renal injury.

Main Methods:

  • Isolated rat kidneys were perfused at different temperatures (30°C, 37°C, and 41°C).
  • Renal structure, function, ATP levels, sodium reabsorption, and oxygen consumption (QO2) were measured.

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  • Statistical analysis was used to compare outcomes between temperature groups.

    • Main Results:

    • Kidneys perfused at 41°C showed extensive tubular damage and decreased function compared to 37°C.
    • Kidneys perfused at 30°C exhibited less damage and better function than at 37°C.
    • Increased temperature (41°C) led to a 50% reduction in renal ATP, despite reduced sodium reabsorption and normal QO2.

    Conclusions:

    • Elevated temperatures exacerbate renal injury and dysfunction in ARF.
    • Increased temperature may uncouple oxygen consumption from sodium transport, depleting ATP.
    • This ATP depletion likely contributes to tubular cell death and renal damage in ARF.