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Proline Metabolism in Tumor Growth and Metastatic Progression
Cristina D'Aniello1, Eduardo J Patriarca1, James M Phang2
1Stem Cell Fate Laboratory, Institute of Genetics and Biophysics "Adriano Buzzati-Traverso", CNR, Naples, Italy.
Frontiers in Oncology
|June 6, 2020
Summary
Cancer cells reprogram metabolism, particularly proline metabolism, to fuel growth and metastasis. Targeting the proline-collagen-epigenetics axis offers new therapeutic strategies for metastatic cancers.
Area of Science:
- Oncology
- Cancer Metabolism
- Biochemistry
Background:
- Cancer cells exhibit remarkable survival, evasion of apoptosis, and therapeutic resistance.
- Metabolic reprogramming supports uncontrolled proliferation and metastasis in cancer.
- Tumor cell heterogeneity is a key driver of cancer aggressiveness and treatment failure.
Purpose of the Study:
- To investigate the role of proline metabolism in cancer development and progression.
- To elucidate the link between proline metabolism, collagen synthesis, and tumor heterogeneity.
- To highlight the potential of targeting the metabolic-epigenetic axis for cancer therapy.
Main Methods:
- Review of existing literature on proline metabolism in cancer.
- Analysis of enzymes involved in proline synthesis and catabolism.
- Discussion of the proposed model linking proline, collagen, and epigenetic regulation.
Main Results:
- Proline metabolism is crucial for cancer cell proliferation, energy production, redox balance, and anaplerosis.
- Proline availability impacts collagen synthesis, maturation, and cancer cell plasticity.
- A cycle of collagen synthesis and degradation influences the epigenetic landscape and tumor heterogeneity.
Conclusions:
- Proline metabolism plays a significant role in driving cancer progression and heterogeneity.
- The interplay between proline metabolism and epigenetic modifications presents a promising therapeutic target.
- Targeting the metabolic-epigenetic axis could lead to effective treatments for metastatic cancers.
Keywords:
ALDH18A1BudesonidePRODHPYCR1collagen prolyl-hydroxylasesepigenetic remodelingmetabolic reprogrammingprolineMore Related Videos
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