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Updated: Dec 19, 2025
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Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
Published on: February 15, 2022
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Minimally Invasive Glaucoma Surgery: Where Is the Evidence?
Kevin Gillmann1, Kaweh Mansouri1,2
1Glaucoma Research Center, Montchoisi Clinic, Swiss Visio, Lausanne, Switzerland.
Summary
Minimally invasive glaucoma surgeries (MIGS) offer tailored treatment options for glaucoma. While effective, more high-quality comparative studies are needed to guide optimal MIGS selection.
Area of Science:
- Ophthalmology
- Surgical Innovation
- Glaucoma Management
Background:
- Glaucoma treatment has rapidly expanded with minimally invasive glaucoma surgeries (MIGS).
- A diverse range of MIGS procedures are now available, offering personalized therapeutic approaches.
Purpose of the Study:
- To review available MIGS procedures.
- To analyze current data guiding the selection of MIGS for glaucoma treatment.
Main Methods:
- Systematic review and meta-analysis of randomized and non-randomized controlled trials.
- Analysis of 77 articles, including 28 comparative studies and 12 RCTs, encompassing 7570 eyes.
- Calculation of weighted mean intraocular pressure reduction for comparative analysis.
Main Results:
- Weighted mean intraocular pressure reductions varied significantly across MIGS procedures.
- Notable reductions observed: Preserflo (50.0%), XEN (38.8%), gonioscopically-assisted transluminal trabeculotomy (36.5%), Hydrus (34.4%), ab interno canaloplasty (36.2%).
- MIGS demonstrated efficiency compared to standalone phacoemulsification.
Conclusions:
- MIGS allow for individualized glaucoma therapy selection.
- High-quality comparative data is essential for informed treatment choices.
- Limited comparative studies exist between different MIGS techniques or against gold-standard treatments.
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