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Gastrointestinal Complications After Cardiac Surgery: Highly Morbid but Improving Over Time
Nathan Haywood1, J Hunter Mehaffey1, Robert B Hawkins1
1Division of Thoracic & Cardiovascular Surgery, Department of Surgery, University of Virginia, Charlottesville, Virginia.
Insights
Gastrointestinal complications after cardiac surgery remain common but are not increasing. While associated with high morbidity and costs, improved quality efforts have led to better long-term survival for these patients.
Area of Science:
- Cardiovascular Surgery
- Gastroenterology
- Surgical Outcomes
- Health Services Research
Background:
- Gastrointestinal (GI) complications following cardiac surgery present significant challenges, contributing to elevated morbidity and mortality rates.
- Understanding the specific impact of individual GI complications is crucial for improving patient outcomes.
- Contemporary data on these complications and their associated costs are essential for evidence-based practice.
Purpose of the Study:
- To analyze the granular impact of various gastrointestinal complications after cardiac surgery.
- To assess the trends and outcomes of these complications over two distinct time periods.
- To evaluate the association of GI complications with morbidity, mortality, length of stay, and long-term survival.
Main Methods:
- A cohort of 6070 patients undergoing cardiac surgery between 2010 and 2017 was identified from an institutional database.
- Patient records were linked with institutional data on gastrointestinal complications and associated costs.
- Patients were divided into early (2010-2013) and current (2014-2017) eras for comparative analysis.
Main Results:
- Gastrointestinal complications occurred in 4.6% of patients, with Clostridium difficile infection and gastrointestinal bleeding being the most frequent.
- These complications were significantly linked to higher rates of major postoperative morbidity, mortality, prolonged hospital stays, and discharge to extended care facilities.
- Despite no change in complication incidence between eras, long-term survival improved in the current era, with adjusted costs remaining higher for affected patients.
Conclusions:
- The incidence of gastrointestinal complications after cardiac surgery has remained stable over time.
- While these complications continue to be associated with substantial resource utilization and morbidity, significant improvements in long-term survival have been observed.
- These improved outcomes underscore the positive impact of quality improvement initiatives in managing patients with GI complications post-cardiac surgery.
Background:
Gastrointestinal complications after cardiac surgery are associated with high morbidity and mortality. We sought to determine the granular impact of individual gastrointestinal complications after cardiac surgery and assess contemporary outcomes.
Materials And Methods:
Patients undergoing cardiac surgery from 2010 to 2017 (6070 patients) were identified from an institutional Society of Thoracic Surgeons database. Records were paired with institutional data assessing gastrointestinal complications and cost. Patients were stratified by early (2010-2013) and current (2014-2017) eras.
Results:
A total of 280 (4.6%) patients experienced gastrointestinal complications including Clostridiumdifficile infection (94, 33.6%), gastrointestinal bleed (86, 30.7%), hepatic failure (66, 23.6%), prolonged ileus (59, 21.1%), mesenteric ischemia (47, 16.8%), acute cholecystitis (17, 6.0%), and pancreatitis (14, 5.0%). Gastrointestinal complications were associated with higher rates of early postoperative major morbidity [206 (73.6%) versus 773 (13.4%), P < 0.0001], mortality [78 (27.9%) versus 161 (2.8%), P < 0.0001], length of stay (23 versus 6 d, P < 0.0001), and discharge to a facility [115 (41.1%) versus 1395 (24.1%), P < 0.0001]. Patients suffering gastrointestinal complications had worse risk-adjusted long-term survival (hazard ratio: 3.0, P < 0.0001) and higher adjusted cost ($9,173, P = 0.05). Between eras, there was no difference in incidence of gastrointestinal complications [139 (4.4%) versus 141 (4.8%), P = 0.51] or rate of specific complications (all P > 0.05). However, long-term survival increased in modern era (P < 0.0001).
Conclusions:
Although incidence of gastrointestinal complications after cardiac surgery has not changed over time, long-term survival has improved. Gastrointestinal complications remain associated with high resource utilization and major morbidity, but patients are now more likely to recover, highlighting the benefit of quality improvement efforts.
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