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Epilepsy and Seizures: Overview

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Related Experiment Video

Updated: Dec 19, 2025

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study

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Parry-Romberg Syndrome and Temporal Lobe Refractory Epilepsy: Case Report.

A Velandia-Martínez¹, M A Ortega-Sanchez¹, S O Martínez-Perez²

¹Department of Neurology, Carlos Ardila Lulle Medical Center, Santander, Colombia.

Journal of Epilepsy Research

|June 9, 2020

Summary

Parry-Romberg syndrome (hemifacial atrophy) is a rare neurocutaneous disease. Early identification of dermatologic, dental, and neurologic symptoms, like refractory epilepsy, is crucial for timely intervention and improved quality of life.

Keywords:

Facial hemiatrophy Hemifacial atrophy Temporal lobe epilepsy

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Area of Science:

Neurology
Dermatology
Genetics

Background:

Parry-Romberg syndrome (PRS), or hemifacial atrophy, is a rare neurocutaneous disorder.
It predominantly affects women, typically manifesting within the first two decades of life.
Etiology is multifactorial, potentially involving genetic, autoimmune, or environmental factors.

Observation:

A case study of a 23-year-old female with left-sided hemifacial atrophy.
The patient presented with dermatologic, dental, and neurological complications.
Refractory temporal lobe epilepsy was a significant neurological manifestation.

Findings:

Neuroimaging and electrodiagnostic tests confirmed refractory temporal lobe epilepsy.
The case highlights the diverse systemic manifestations of PRS.
Timely diagnosis and intervention are critical for managing PRS progression.

Implications:

Early recognition of PRS symptoms can guide therapeutic strategies.
Prompt management may halt disease progression and enhance patient quality of life.
This case underscores the importance of a multidisciplinary approach in managing rare neurocutaneous diseases.