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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Updated: Dec 19, 2025

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
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RNA Therapy: Current Status and Future Potential.

Young-Kook Kim1

  • 1Department of Biochemistry, Chonnam National University Medical School, Hwasun, Korea.

Chonnam Medical Journal
|June 9, 2020
PubMed
Summary
This summary is machine-generated.

RNA therapy utilizes diverse RNA molecules to target cellular pathways for treating diseases. This review covers RNA drug development, delivery, and future potential, highlighting advantages over traditional therapies.

Keywords:
Aptamers, NucleotideNanoparticlesRNA InterferenceRNA, AntisenseRNA, Small Interfering

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Area of Science:

  • Molecular Biology
  • Genetics
  • Pharmacology

Background:

  • Diverse RNA molecules, including noncoding RNAs, regulate cellular pathways and are emerging as therapeutic targets.
  • RNA-based therapeutics have advanced significantly, with antisense and small interfering RNA drugs now in clinical use.
  • The development of RNA aptamer and messenger RNA drugs is an active area of research.

Purpose of the Study:

  • To review the history and fundamental concepts of RNA therapy.
  • To discuss current RNA-based drugs in clinical trials and on the market.
  • To explore the future potential and delivery strategies for RNA therapeutics.

Main Methods:

  • Literature review of RNA therapy history, mechanisms, and drug development.
  • Analysis of clinical trial data and approved RNA-based drugs.
  • Discussion of RNA drug delivery systems and future research directions.

Main Results:

  • RNA-based drugs, including antisense and small interfering RNAs, have reached clinical application.
  • Various RNA drug delivery strategies are being developed for efficient cellular uptake.
  • RNA therapy offers a broad therapeutic potential, targeting all genes within cells.

Conclusions:

  • RNA therapy represents a promising frontier in medicine with significant advantages over conventional treatments.
  • Continued research into RNA mechanisms and delivery systems will expand therapeutic applications.
  • RNA-based drugs are poised to revolutionize treatment for a wide range of human diseases.