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Updated: Dec 19, 2025

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
Published on: November 12, 2015
Technique for pediatric corneal crosslinking under general anesthesia.
Simon S M Fung1, Melanie Mason2, Daniel M Gore2
1Department of Ophthalmology, University of California Los Angeles.
Corneal cross-linking (CXL) under general anesthesia offers a safe alternative for pediatric patients. This modified technique, including bilateral simultaneous CXL, reduces surgical time and ensures patient comfort.
Area of Science:
- Ophthalmology
- Surgical Techniques
Background:
- Corneal cross-linking (CXL) is standard for treating progressive corneal ectasias.
- Topical anesthesia for CXL is challenging in pediatric and uncooperative patients.
Purpose of the Study:
- To describe a novel technique for performing CXL under general anesthesia.
- To introduce a time-saving bilateral simultaneous CXL procedure.
- To evaluate the safety and efficacy in pediatric patients.
Main Methods:
- CXL performed under sevoflurane and propofol general anesthesia.
- Eye stabilization using laryngeal airway/nasal oxygen cannulas and forceps/microsponges.
- Bilateral simultaneous CXL performed in a staggered manner.
- Multimodal analgesia administered postoperatively.
Main Results:
- 21 eyes of 13 pediatric subjects (≤18 years) treated.
- Median follow-up of 14.5 months.
- One case of sterile corneal infiltrate, resolved with corticosteroids.
- Up to 25% reduction in surgical time achieved.
Conclusions:
- General anesthesia CXL is a viable and safe option for pediatric patients.
- Bilateral simultaneous CXL is efficient, reducing operative time.
- The technique ensures patient comfort and minimizes complications.
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