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Updated: Dec 18, 2025

Isolation of Primary Human Colon Tumor Cells from Surgical Tissues and Culturing Them Directly on Soft Elastic Substrates for Traction Cytometry
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Targeting Tissue Stiffness in Metastasis: Mechanomedicine Improves Cancer Therapy
Jian Zhang1, Cynthia A Reinhart-King1
1Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA.
Abstract:
Tissue stiffening plays a critical role in cancer progression. In this issue of Cancer Cell, Shen et al. demonstrated that highly activated fibroblasts in metastatic colorectal cancer increase tissue stiffness and angiogenesis. Targeting tissue stiffness improves the outcome of anti-angiogenic therapy and prolongs patient survival.
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