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Updated: Dec 18, 2025
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Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
Published on: September 9, 2012
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Factor VII Deficiency in Patients Receiving Chronic Packed Cell Transfusions
Abed Abu-Quider1, Mahdi Asleh, Yariv Fruchtman
1Department of Pediatric Hematology Oncology, Saban Pediatric Medical Center, Soroka University Medical Center, Ben Gurion University of the Negev, Beer Sheva, Israel.
Journal of Pediatric Hematology/Oncology
|June 11, 2020
Summary
This study found mild factor VII deficiency in most transfusion-dependent patients, a condition previously unreported. Despite low levels, these patients showed no significant bleeding issues under normal conditions.
Area of Science:
- Hematology
- Coagulation Disorders
Background:
- Acquired factor VII deficiency is a rare coagulopathy.
- This condition has not been previously documented in transfusion-dependent patients.
Purpose of the Study:
- To investigate the prevalence of factor VII deficiency in transfusion-dependent patients.
- To analyze coagulation profiles, factor levels, and bleeding history in this cohort.
Main Methods:
- Retrospective review of 26 transfusion-dependent patients' medical records.
- Analysis of coagulation profiles, factor V and VII levels.
- Assessment of potential environmental factors and bleeding history.
Main Results:
- Mild factor VII deficiency (levels 35-56%) was identified in 89.6% (26 of 29) of patients.
- No significant bleeding history was reported in the affected patients.
- Factor V levels were also assessed in the patient group.
Conclusions:
- Transfusion-dependent patients may exhibit mild factor VII deficiency.
- This deficiency appears to present without a notable bleeding tendency in physiological states.
- Further research may elucidate the implications of this finding.
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