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Related Experiment Video

Updated: Dec 18, 2025

Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer
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Smart Nanotheranostics Responsive to Pathological Stimuli.

Alessandro Parodi1, Magdalena Rudzinska1, Stefano Leporatti2

  • 1Institute of Molecular Medicine, Sechenov First Moscow State Medical University, Moscow, Russia.

Frontiers in Bioengineering and Biotechnology
|June 12, 2020
PubMed
Summary

Smart nanotheranostics offer dual diagnostic and therapeutic functions for diseases. These advanced nanocarriers respond to pathological triggers for targeted treatment and imaging.

Keywords:
Enzyme-responsive theranosticsROS-responsive theranosticsnanotheranosticspH-responsive theranosticssmart nanoparticles

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Materials Science

Background:

  • Nanotheranostics integrate diagnostic and therapeutic capabilities in single nanocarriers.
  • Current research focuses on multi-functional nanocarriers for enhanced disease treatment.
  • Targeting, multimodal imaging, and synergistic therapies are key features of advanced nanotheranostics.

Purpose of the Study:

  • To review recent advancements in smart nanotheranostics.
  • To explore nanocarrier designs responsive to pathological stimuli.
  • To highlight materials used in developing disease-specific nanotheranostics.

Main Methods:

  • Review of current literature on nanotheranostics.
  • Analysis of nanocarrier mechanisms triggered by pathological conditions.
  • Focus on materials science in nanotheranostic development.

Main Results:

  • Nanotheranostics can be designed to respond to specific pathological triggers like pH, oxidative stress, and enzymes.
  • Trigger-responsive nanotheranostics enable localized therapeutic and diagnostic activation.
  • Diverse materials are being utilized to create sophisticated nanocarrier systems.

Conclusions:

  • Smart nanotheranostics represent a promising frontier in disease treatment.
  • Responsive nanocarriers offer precise control over therapeutic and diagnostic actions.
  • Material selection is crucial for developing effective nanotheranostic platforms.