PSYCHOPATHOLOGICAL DISORDERS AS COMORBIDITY IN PATIENTS WITH PSORIASIS (REVIEW)

Psoriasis is a systemic immune-mediate disease associated with increased risk of comorbidities. Psychopathological disorders in patients with psoriasis remain poorly understood, despite the large number of publications. The aim of the study is to discuss psychological and mental disorders in patients with psoriasis and identify possible common mechanisms of pathogenesis based on the analysis of data of relevant scientific literature. The development of psoriasis is associated with the expressed negative emotions in more than half of patients. Most psoriasis patients indicate a negative impact of the disease on quality of life. The main comorbidity of psychological and psychiatric psoriasis include alexithymia, anxiety and depression including sexual and sleep disorders. Mental and psychological disorders in patients may be primary, but more often secondary to psoriasis. Studies show the involvement of inflammatory mediators (proinflammatory cytokines) and melatonin in the pathogenesis of both psoriasis and psychopathological disorders, with immune inflammation being a key link. Assessment of psychological and psychiatric status will allow timely identification of comorbid pathology and will optimize the therapeutic tactics of treating patients with psoriasis.