[BONE REGENERATION AFTER THE FILLING OF DEFECTS BY GRANULES OF CERAMIC BIOMATERIAL BIOMIN TGG-2]

Purpose of the study - to study the features of bone regeneration under conditions of filling metadiaphyseal defects with granules of biphasic calcium phosphate with β-tricalcium phosphate of a needle structure. The study was conducted on 24 white laboratory rats. А metadiaphyseal defect (3 mm) was reproduced in the distal femur with dental boron, followed by its filling with granules of TGg-2 ceramic biomaterial. Rats were removed from the experiment on days 7, 14, 28, and 56; histological methods examined the area of the defect filled with granules. Bone regeneration in a defect filled with granules proceeds in accordance with the general characteristics of reparative osteogenesis. There is a sequence of tissues formation, fibroreticular and bone, with a subsequent increase in the area and maturity of bone tissue for the duration of the study. Bone tissue was formed directly on the surface and between the granules, for a finite period (56 days) 2.2 times the area of fibroreticular tissue. Granules in the defect occupied more than 60% of its area. A characteristic feature was a pronounced macrophage reaction and resorption of granules by multinucleated cells, defined as osteoclasts. Biomin TGg-2, a new ceramic biomaterial, is biphasic calcium phosphate with a composition of needle-shaped hydroxylapatite and β-tricalcium phosphate, has biocompatible and high osteoconductive qualities, as evidenced by the location of fibroblasts and osteoblasts on the surface of the granules and the formation of bone tissue directly on the granules. The biomaterial does not cause a chronic inflammatory reaction.