Sensitive marker for evaluation of hypertensive heart disease: extracellular volume and myocardial strain

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Quantification of Mouse Heart Left Ventricular Function, Myocardial Strain, and Hemodynamic Forces by Cardiovascular Magnetic Resonance Imaging
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Quantification of Mouse Heart Left Ventricular Function, Myocardial Strain, and Hemodynamic Forces by Cardiovascular Magnetic Resonance Imaging

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Junqiao Niu1, Mu Zeng2, Yan Wang3

  • 1Radiological imaging Center, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, 830001, China.

BMC Cardiovascular Disorders
|June 17, 2020
PubMed

Insights

Extracellular volume (ECV) and myocardial strain parameters effectively monitor hypertensive heart disease (HHD) progression and treatment response. While ECV, global radial strain, and global circumferential strain improve post-treatment, longitudinal strain remains challenging to enhance in HHD patients.

Area of Science:

  • Cardiology
  • Medical Imaging

Background:

  • Hypertensive heart disease (HHD) evaluation relies on assessing left ventricular (LV) fibrosis and hypertrophy.
  • Extracellular volume (ECV) and myocardial strain parameters indirectly reflect these changes, offering insights into LV remodeling.

Purpose of the Study:

  • To analyze ECV and strain parameter characteristics in HHD patients with varying systolic dysfunction.
  • To explore the impact of hypertension treatment on these myocardial parameters.

Main Methods:

  • 62 HHD patients were grouped by ejection fraction (EF) and compared to controls.
  • Cardiac magnetic resonance (CMR) assessed ECV and LV strain (radial, circumferential, longitudinal) pre- and post-antihypertensive treatment in 21 patients.

Main Results:

  • HHD groups showed higher ECV than controls, with no significant inter-group differences.
  • Decreasing EF correlated with reduced absolute strain values; strain related to LV mass and ECV.
  • ECV, global radial strain (GRS), and global circumferential strain (GCS) improved post-treatment, unlike longitudinal strain (LS).

Conclusions:

  • ECV and strain parameters are sensitive indicators of myocardial abnormalities in HHD.
  • ECV, GRS, and GCS are more responsive to treatment than LS.
  • These parameters serve as valuable markers for monitoring HHD treatment efficacy.
Abstract

Keywords:
CMRECVHHDMyocardial strain

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